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75TH ANNIVERSARY OF FIRST TRANSPACIFIC FLIGHT TO BE CELEBRATED MAY 31 IN OAKLAND. OAKLAND-TO-AUSTRALIA FLIGHT THAT OPENED PACIFIC TO AIR TRAVEL FEATURE OF WESTERN AEROSPACE MUSEUM COMMEMORATIVE EVENTS AND QANTAS AIRWAYS HISTORIC REENACTMENT

By Anonymous

Oakland International Airport May 29, 2003 -- The Western Aerospace Museum hosts a daylong 75th anniversary commemoration this Saturday, May 31, of the first crossing of the Pacific Ocean by air. The historic flight departed May 31, 1928 from what is now Oakland Airport’s North Field. Its crew included Australian aviators Charles Kingsford Smith and Charles Ulm, and American team members, navigator Harry Lyon and radio operator James Warner.

Commemoration activities include the 11 a.m. arrival of a Qantas Airways flight reenactment aircraft, a newly delivered Boeing 737-800, and a luncheon at the Western Aerospace Museum followed by an afternoon program examining the original flight. The Qantas Airways reenactment flight will depart Oakland International’s North Field at 4 p.m., retracing the original long-distance flight path to Sydney, Australia via Hawaii, Fiji and Brisbane. An evening reception and dinner follows at the museum beginning at 6:30 p.m.

The afternoon program examining the historic flight will include an interactive multi-media presentation that will also feature appearances by relatives and associates of the crew of the original flight’s aircraft, the Southern Cross. Guests are expected to include Charles Kingsford Smith, son of the pilot; Charles Ulm, grandson of the co-pilot; Tom Warner, son of the radio operator; Ed Lyon son of navigator Harry Lyon; and Jane McGovern, great granddaughter of George Hancock, the businessman who donated the plane and the money to make the trip possible. The program will be introduced and emceed by Ron Reuther, president emeritus of the Western Aerospace Museum.

The dinner program will feature a presentation by Howard Goldberg, vice president, Qantas Airways and radio updates on the reenactment flight’s progress from Captain Alex Passerini en route to Honolulu. A documentary film about the 1928 flight as well as footage of radio operator Lyon and navigator Warner will also be viewed.

Cost for the afternoon program is $15 with and $5 without lunch. The evening dinner program cost is $50.

The 75th anniversary celebration is endorsed by the Centennial of Flight Celebration Commission, Fijian Consul General, Australian American Chamber of Commerce, Port of Oakland, and the Western Aerospace Museum and will feature an opportunity to meet relatives of the original crew and hear their personal recollections of a time and place that should be forever remembered in aviation history.

For more information and to make reservations, visit www.westernaerospacemuseum.org or call the museum at 510-638-7100.

The Western Aerospace Museum mission is to collect, preserve and present aviation history of the Bay Area and Northern California. It was incorporated in January l98l. The founder was Ronald Reuther. The Museum opened in l986 in hangar five at Oakland Airport’s historic North Field. In 1988, the Museum was relocated to its present location, a wood and corrugated metal hangar built by the Boeing School of Aeronautics in 1940. School and other community groups routinely visit and use the Museum, which is open to the public Wednesday through Sunday and many holidays. For more information, visit www.westernaerospacemuseum.org.



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Retinoids : An A-Z guide to their biology, therapeutic opportunities & pharmaceutical development

By Anonymous

The retinoids play a key role in differentiation, proliferation and apoptosis and as a result over 30 naturally occurring and synthetic analogs of retinoic acid are now either in development or on the market. Retinoids in current use are effective in only a small number of cancers as well as acne and psoriasis. Extending this benefit to other types of cancer as well as newer indications such as diabetes and airway inflammation has represented a hurdle that will only be fully overcome by taking into account the biology of the retinoids. LeadDiscovery’s "Retinoids: An A-Z guide to their biology, therapeutic opportunities & pharmaceutical development" represents one of the most comprehensive insights into the retinoid field published in recent years. The aim of this report is to bring the reader up to date with advances in this area, pharmaceutical activity relating to retinoid development and strategies that will lead to the identification of improved retinoids.

Available retinoids are effective in treating acne and psoriasis. Likewise the retinoids are also beneficial in the treatment of acute promyelocytic leukemia, skin cancer, Kaposi's sarcoma and cutaneous T cell lymphoma. This has led to the launch of Ligand Pharmaceuticals' three marketed retinoids Tagretin gel, Tagretin capsules and Panretin which are indicated for T cell lymphoma or Kaposi's sarcoma. Although the incidence of these cancers is relatively low Ligand's retinoids generated sales of $57 million in 2002.

Although numerous cancers are associated with alterations in retinoid biology, clinical efficacy of retinoids has been limited - understanding why, and how this "resistance" can be overcome therefore represents a major goal in oncology. Meeting this goal will extend the therapeutic benefit of the retinoids to other major cancers as well as other newer indications for the retinoids such as diabetes and COPD. These advances would be attractive both clinically and commercially.

Early clinical studies and retinoid development commenced without an understanding of retinoid molecular biology. It is now clear that the actions of these molecules are, in almost all cases, via their nuclear receptors, whereby they are able to impinge on the expression of multiple genes. It is therefore not surprising that a "shotgun" approach to the retinoids has generally produced disappointing results in the clinic.

"Retinoids : An A-Z guide to their biology, therapeutic opportunities & pharmaceutical development" takes the reader on a journey through the various field of retinoid biology and is designed to offer an insight into how the retinoids confer specificity under physiological conditions; the pathophysiology of the retinoids; and pharmaceutical strategies that may increase the therapeutic benefits of the retinoids. In particular the report overviews

- biochemical and cellular pathways controlling retinoid uptake

- retinoid synthesis and metabolism

- the biology of the various proteins that shuttle the retinoids from cell to cell and onwards to their site of action

- the various retinoid nuclear receptor complexes, their ligands and their interaction with the genome

- modulation of nuclear receptor-conferred control of transcription by co-repressors and co-activators

- the role of the retinoids in the pathophysiology of cancer as well as animal and clinical data surrounding the therapeutic use of the retinoids

- retinoids in development or on the market

One of the main focuses of this report is the regulation of gene expression by nuclear receptor dimers and how plasticity has evolved within this system. The RXR receptor has emerged as a key binding partner, forming dimers with RAR receptors as well as members of the other nuclear receptor families. Each dimer is able to bind a specific set of DNA response elements, and the multiplicity of isoforms and splice variants of each receptor introduces a basic level of plasticity. Therefore during the drug development process one is faced with the choice of advancing molecules with mixed or selective activity. Since a large number of receptor subtypes exist, it is possible to adopt the middle ground - for example, Allergan have developed Tazarotene, which was the first of a new generation of receptor-selective retinoids targeting RARb and RARg.

The make-up of a particular dimer not only determines which genes it can influence, but it also determines which of the many co-regulatory molecules it may bind. The large number of possible dimer/co-regulatory complexes adds a further level of plasticity, through what has been termed the "co-factor code". Challenges of the future will include the selection of gene targets and the identification of dimer-co-regulatory complex(es) that play a role in the control of these genes. This report provides a full inventory of known co-regulatory molecules. Advances in genomics are allowing gene expression profiles to be identified for particular disease states and gene targeting is already aiding the drug development process. It is now hoped that the identification of dimer/co-regulatory complexes able to regulate the expression of these target genes will soon become a common feature of therapeutic development.

In short this report offers an overview of the history, a full account of the present and a view into the future of the retinoids and their therapeutic potential.

Following an expansion of LeadDiscovery's PharmaceuticalSolutions service we are now able to provide expert advice on medicinal chemistry surrounding the development of retinoid ligands, chemical libraries of candidate modulators and screening services to assay such libraries. Consequently, this dossier like all of our dossiers not only offers a strategic insight into this field and an opportunity to expedite target selection but they can also be used as a platform from which to rapidly develop therapeutic candidates.

For further details and to access this dossier visit the following address:

http://www.leaddiscovery.co.uk/reports/retinoids.html

Other reports of interest:

Targeting endogenous inhibitors of apoptosis: Opportunities for the treatment of cancer, stroke and MS

Histone deacetylase inhibitors: Redefining pharmaceutical approaches to the treatment of cancer

For further information on LeadDiscovery please visit our website at www.leaddiscovery.co.uk


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SOUTHWEST AIRLINES EXTENDS ITS DISCOUNT AIR FARES; Cheap Air Fares Systemwide are Extended

By Anonymous

DALLAS-Jan. 30, 2004-Customers of Southwest Airlines can still take advantage of discount air fares. The airline is extending its cheap air fares systemwide. Customers now can purchase cheap airline tickets through February 26, 2004, for travel beginning February 13, 2004, through the end of the published schedule (currently June 11, 2004).

“Our Customers have overwhelmingly responded to the discount air fares,” said Joyce Rogge, senior vice president marketing for Southwest Airlines. “With this extension of our air fare sale, Customers will be able to keep enjoying travel for as little as $39 each way.”

As shown in the breakdown below, there are three different discount air fares available:

Systemwide Sale (* fare rules below)
The fares range from $39 to $139 each way and vary by destination and day of travel. Fares range from $39 to $99 each way on off-peak days (Tuesday, Wednesday, and Saturday) and from $44 to $139 each way on the busier peak days (Sunday, Monday, Thursday, and Friday). Some fare examples are shown below.

Sample Off-Peak Fares
 $39 each way between Los Angeles and Phoenix and between Baltimore/Washington and Norfolk/Southern Virginia.
 $99 each way between Baltimore/Washington and San Jose and between Detroit Metro and Phoenix.

Sample Peak Fares
 $44 each way between Chicago Midway and Indianapolis and between Seattle and Spokane.
 $139 each way fares between Seattle and Albuquerque and between Raleigh/Durham and Phoenix.

California (* fare rules below)
Air fares are just $39 each way in Southwest’s intra-California markets. For example, Californians can enjoy the $39 each-way fares between Los Angeles and Sacramento, between Burbank and Oakland, between Ontario and San Jose, and between San Diego and Oakland.

Texas, Oklahoma, and Arkansas (* fare rules below)
Southwest Airlines also is offering Customers discount air fares for travel within Texas, Oklahoma, and Arkansas. Customers will pay only $34 or $60 each way on select flights. For instance, Customers will pay only $34 each way between Houston and San Antonio, between Amarillo and Dallas Love Field, and between Austin and Lubbock. Examples of the $60 each-way airline fares are between Oklahoma City and San Antonio, between Austin and El Paso, and between Little Rock and Tulsa.

Fare Rules
    Fares are only available each way with roundtrip purchase and require an overnight stay (any night). The fares are available for purchase Jan. 30, 2004, through Feb. 26, 2004, and are valid for travel from Feb. 13, 2004, through the end of the published schedule (currently June 11, 2004). Roundtrip tickets must be purchased within one day of making reservations and at least 14 days before departure. Seats are limited and will not be available on some flights that operate during very busy travel times and holiday periods such as Memorial Day. Blackout dates apply to all Florida markets on March 18, 2004, through April 11, 2004. Fares do not include up to a $3.10 federal segment tax per takeoff and landing. Fares do not include airport-assessed passenger facility charges (PFC) of up to $18 roundtrip and federal September 11th Security Fees of up to $10 roundtrip per person. Fares are subject to change until ticketed. Tickets are nonrefundable but (except for tickets purchased through our Group Tickets program) may be applied toward the purchase of future travel on Southwest Airlines. Fares are valid on published, scheduled service only. Any change in itinerary could result in an increase in fare. Fares are not necessarily common rated in Houston, the Bay Area, or the LA Basin.
Customers who book their travel via the Internet can subscribe to Southwest’s Click ‘n Save e-mail updates. The weekly updates deliver the airline’s latest fare sale information right to the Customer’s e-mail “in” box. For more information, visit www.southwest.com/email.
www.southwest.com

Media Please Contact:
Public Relations at 214/792-4847



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